Following the release of Windows Phone, Microsoft undertook a gradual rebranding of its product range throughout 2011 and 2012, with the corporation’s logos, products, services, and websites adopting the principles and concepts of the Metro design language. The initiative is meant to speed innovation through simple software changes in telecommunications networks, wireless networks, data centers, and other networking areas. It launched an alliance with Nokia in 2011 and Microsoft worked closely with the company to co-develop Windows Phone, but remained partners with long-time Windows Mobile OEM HTC.
Welcome to the Microsoft 365 Copilot app
- Microsoft is one of only two U.S.-based companies that have a prime credit rating of AAA.
- December also saw the company discontinue the Microsoft Edge Legacy browser project in favor of the “New Edge” browser project, featuring a Chromium based backend.
- Until a real solution is offered, we have made the difficult decision to completely disable access to our website in Virginia.
- Founded by Bill Gates and Paul Allen to market BASIC interpreters for the Altair 8800, Microsoft rose to dominate the personal computer operating system market with MS-DOS in the mid-1980s, followed by Windows.
It created one of the world’s largest private bus systems, the “Connector”, to transport people from outside the company; for on-campus transportation, the “Shuttle Connect” uses a large fleet of hybrid cars to save fuel. Microsoft’s timeline for phasing out brominated flame retardant (BFRs) and phthalates in all products was 2012 but its commitment to phasing out PVC is not clear. Microsoft is ranked on the 17th place in Greenpeace’s Guide to Greener Electronics (16th Edition) that ranks 18 electronics manufacturers according to its policies on toxic chemicals, recycling, and climate change. At the time, data centers consumed up to 2% of all global electricity, and this amount was projected to increase. In 2015, Microsoft established its own parental leave policy to allow 12 weeks off for parental leave with an additional 8 weeks for the parent who gave birth. In August 2018, Microsoft implemented a policy for all companies providing subcontractors to require 12 weeks of paid parental leave to each employee.
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Nevertheless, this study provides valuable insights into potential first-line treatment options for advanced ICC and suggests several directions for future research. Additionally, the study population was younger and healthier than typical ICC patients encountered in clinical practice, which may have favorably influenced outcomes. Importantly, no treatment-related deaths occurred in either arm, suggesting both approaches have acceptable safety profiles for this patient population. Notably, a high proportion of patients in both arms (approximately 77%) were positive for hepatitis B markers, reflecting the epidemiological landscape in the region.
CCA Clinical Trials Focused on DNA Repair Deficiencies
Microsoft initially moved onto the grounds of the campus on February 26, 1986, weeks before the company went public on March 13. In February 2010, however, Microsoft took a stance against adding additional public transport and high-occupancy vehicle (HOV) lanes to the State Route 520 and its floating bridge connecting Redmond to Seattle; the company did not want to delay the construction any further. In 2011, Greenpeace released a report rating the top ten big brands in cloud computing on the sources of electricity for their data centers.
In October 2021, Microsoft announced that it began rolling out end-to-end encryption (E2EE) support for Microsoft Teams calls in order to secure business communication while using video conferencing software. In the same month, Microsoft acquired Australia-based video editing software company Clipchamp. On September 21, 2020, Microsoft announced its intent to acquire video game company ZeniMax Media, the parent company of Bethesda Softworks, for about $7.5 billion, with the deal expected to occur in the second half of 2021 fiscal year. In February 2019, hundreds of Microsoft employees protested the company’s war profiteering from a $480 million contract to develop virtual reality headsets for the United States Army. During the summer of 2015 the company lost $7.6 billion related to its mobile-phone business, firing 7,800 employees.
What Are the Implications for Future Clinical Practice?
These findings represent an important step forward in the evolving treatment landscape for this challenging malignancy and warrant further investigation in larger confirmatory trials. How might the differing toxicity profiles of these regimens influence treatment selection in real-world clinical settings? Could baseline immune parameters, such as neutrophil counts, serve as predictive biomarkers for selecting patients most likely to benefit from immunotherapy-based approaches?
1994: Windows and Office
In June 2024, Microsoft faced a potential EU fine after regulators accused it of abusing market power by bundling its Teams video-conferencing app with its Office 365 and Microsoft 365 software. Microsoft was the first company to participate in the PRISM surveillance program, according to leaked NSA documents obtained by The Guardian and The Washington Post in June 2013, and acknowledged by government officials following the leak. When the Internal Revenue Service audited these transactions, ProPublica reported that Microsoft aggressively fought back, including successfully lobbying Congress to change the law to make it harder for the agency to conduct audits of large corporations. As reported by several news outlets, an Irish subsidiary of Microsoft based in the Republic of Ireland declared £220 bn in profits but paid no corporation tax for the year 2020. This characterization is derived from the perception that Microsoft provides nearly everything for its employees in a convenient place, but in turn overworks them to a point where it would be bad for their (possibly long-term) health.
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In March 2024, Inflection AI’s cofounders Mustafa Suleyman and Karen Simonyan announced their departure from the company in order to start Microsoft AI, with Microsoft acqui-hiring nearly the entirety of its 70-person workforce. On November 20, 2023, Satya Nadella announced that Sam Altman, who had been ousted as CEO of OpenAI just days earlier, and Greg Brockman, who had resigned as president, would join Microsoft to lead a new advanced AI research team. In January 2023, CEO Satya Nadella announced Microsoft would lay off some 10,000 employees. In December 2022, Microsoft announced a new 10-year deal with the London Stock Exchange Group for products including Microsoft Azure; Microsoft acquired around 4% of LSEG as part of the deal. Microsoft has not released statements regarding Activision’s recent legal controversies regarding employee abuse, but reports have alleged that Activision CEO Bobby Kotick, a major target of the controversy, will leave the company after the acquisition is finalized. On January 18, 2022, Microsoft announced the acquisition of American video game developer and holding company Activision Blizzard in an all-cash deal worth $68.7 billion.
In January 2018, Microsoft patched Windows 10 to account for CPU problems related to Intel’s Meltdown security breach. Microsoft planned to launch a preview of Intune for Education “in the coming weeks”, with general availability scheduled for spring 2017, priced at $30 per device, or through volume licensing agreements. In November 2016, Microsoft joined the Linux Foundation as a Platinum member during Microsoft’s Connect(); developer event in New York.
The Boycott, Divestment and Sanctions movement added Microsoft to its list of targets for partnering “with the apartheid regime of Israel and its prison system”. On March 20, 2025, before an event at Seattle’s Great Hall with Brad Smith and Steve Ballmer, protestors projected “Microsoft powers genocide” on the wall. Microsoft’s Teams usage soared during the pandemic, growing from 2 million daily users in 2017 to 300 million in 2023. Negotiations with the European Commission continued until the summer of 2023, but reached an impasse that led to Microsoft facing an antitrust investigation from the European Union. In 2020, Salesforce, the manufacturer of the Slack platform, complained to European regulators about Microsoft due to the integration of the Teams service into Office 365. People who use its products and services often end up becoming dependent on them, a process known as vendor lock-in.
- In May 2016, Microsoft announced another 1,850 job cuts mostly in its Nokia mobile phone division.
- In Arm A, the most common adverse events included fatigue (71%), paresthesia (45%), gingivitis (45%), and immune-related events such as hypothyroidism (71%).
- Conversely, in Arm B, responders showed decreases in neutrophil and basophil proportions with increased monocyte proportions after treatment, suggesting different immune modulation mechanisms between the two approaches.
- The safety of our users is one of our biggest concerns.
- The primary objectives include ORR and PFS, and secondary objectives include safety, tolerability, and OS.
To cope with the potential for an increase in demand for products and services, Microsoft opened a number of “holiday stores” across the U.S. to complement the increasing number of “bricks-and-mortar” Microsoft Stores that opened in 2012. The Surface was unveiled on June 18, becoming the first computer in the company’s history to have its hardware made by Microsoft. A developer preview was released on September 13, which was subsequently replaced by a consumer preview on February 29, 2012, and released to the public in May.
The current study’s results compare favorably with these benchmarks, suggesting that both lenvatinib-based combinations deserve further investigation as potential first-line options. Similarly, the KEYNOTE-966 trial demonstrated that pembrolizumab combined with gemcitabine and cisplatin extended median OS to 12.7 months versus 10.9 months with chemotherapy alone. The TOPAZ-1 trial showed that adding durvalumab to gemcitabine plus cisplatin improved two-year overall survival to 23.6% compared to 11.5% with chemotherapy alone. Conversely, in Arm B, responders showed decreases in neutrophil and basophil proportions with increased monocyte proportions after treatment, suggesting different immune modulation mechanisms between the two approaches.
CCA Clinical Trials Focused on IDH Mutations
Rare Disease Advisor, a trusted source of medical news and feature content for healthcare providers, offers clinicians insight into the latest research to inform clinical practice and improve patient outcomes. Diana earned her PhD and PharmD with distinction in the field of Medicinal and Pharmaceutical Chemistry at the Universidade do Porto. The primary endpoint of the study is the incidence of adverse effects. Secondary objectives include OS, PFS, ORR, DoR, disease control rate at 12 weeks (DCR-12), immunogenicity, and pharmacodynamics in both monotherapy and combination settings. The primary objectives include ORR and PFS, and secondary objectives include safety, tolerability, and OS. The primary endpoint is ORR with secondary endpoints of PFS, OS, and safety.
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On March 13, 2020, Gates announced that he is leaving the board of directors of Microsoft and Berkshire Hathaway to focus more on his philanthropic efforts. Microsoft is ranked No. 14 in the 2022 Fortune 500 rankings of the largest United States corporations by total revenue; and it was the world’s largest software maker by revenue in 2022 according to Forbes Global 2000. On July 2, 2025, Microsoft announced it would cut nearly 4% of its workforce, around 9,000 jobs, to control costs amid heavy AI infrastructure spending, while also restructuring management and streamlining operations. The company previously restructured operations in Russia in June 2022 after being significantly impacted by the Russian invasion of Ukraine, but stated those restructuring efforts have failed. On February 28, 2025, Microsoft announced that Skype would be shutting down on May 5, 2025, to streamline its focus on Microsoft Teams.
In April 2021, Microsoft announced it would buy Nuance Communications for approximately $16 billion. On November 10, 2020, Microsoft released the Xbox Series X and Xbox Series S video game consoles. On February 20, 2019, Microsoft said it would offer its cyber security service AccountGuard to 12 new markets in Europe, including Germany, France and Spain, to close security gaps and protect customers in the political space from hacking. December also saw the company discontinue the Microsoft Edge Legacy browser project in favor of the “New Edge” browser project, featuring a Chromium based backend. In December 2018, Microsoft announced Project Mu, an open source release of the Unified Extensible Firmware Interface (UEFI) core used in Microsoft Surface and Hyper-V products. In August 2018, Toyota Tsusho began a partnership with Microsoft to create fish farming tools using the Microsoft Azure application suite for Internet of things (IoT) technologies related to water management.
The non-comparative nature of the trial design also prevents direct statistical comparison between the two treatment approaches. Notably, this trial builds upon recent advances in ICC treatment demonstrated in other landmark studies. The vegas casino study also evaluated the relationship between peripheral blood markers and treatment response through univariate logistic regression analysis. This finding suggests that baseline immune parameters might help identify patients most likely to benefit from immunotherapy-containing regimens.
The joint operation targeted a sophisticated ecosystem that allowed criminals to exploit stolen information on a massive scale. On May 23, 2025, it was reported that Europol’s European Cybercrime Centre has worked with Microsoft to disrupt Lumma Stealer, a significant infostealer threat. The UK’s Information Commissioner’s Office monitored the situation and noted the adjustments, which included enhanced security measures like encryption and biometric access. Despite CrowdStrike’s CEO George Kurtz clarifying that the issue was not a cyberattack, the incident had widespread consequences, leading to delays in air travel, financial transactions, and medical services globally. In July 2024, it was reported that the company was laying off its diversity, equity, and inclusion (DEI) team.
The study, conducted at Zhongshan Hospital of Fudan University, compared lenvatinib plus toripalimab versus lenvatinib plus chemotherapy, demonstrating significant improvements in patient survival rates and manageable safety profiles. Microsoft had announced it would be bringing employees back to the office at least three days a week starting next month. The probe scrutinized Microsoft’s bundling of cloud services with products like Office and security tools, as well as its growing AI presence through its partnership with OpenAI.
Other companies like Borland, WordPerfect, Novell, IBM and Lotus, being much slower to adapt to the new situation, would give Microsoft market dominance. Following Bill Gates’s internal “Internet Tidal Wave memo” on May 26, 1995, Microsoft began to redefine its offerings and expand its product line into computer networking and the World Wide Web. In 1990, the Federal Trade Commission examined Microsoft for possible collusion due to the partnership with IBM, marking the beginning of more than a decade of legal clashes with the government.
